Please read the Package Leaflet for a full list of contraindications, warnings, precautions and side-effects.


Utrogestan 100mg contains soybean lecithin.  As there is a possible relationship between allergy to soya and allergy to peanut, people with soya or peanut allergy are advised to avoid using Utrogestan 100mg.  For the avoidance of doubt, Utrogestan 100mg does not contain peanut products.

Side effect reporting

Like all medicines, this medicine can cause side effects, although not everyone gets them.

The following side effects have been reported since Utrogestan (Progesterone) 100 mg came on the market and may happen with Utrogestan taken orally:

Frequency not known(frequency cannot be estimated from the available data):

  • Stomach pain
  • Nausea (sickness in the stomach)
  • Tiredness
  • Headache
  • Drowsiness
  • Dizziness
  • Vaginal bleeding
  • Intense itching (pruritus)

During clinical trials, the following side effects have also been observed: Frequency not known (frequency cannot be estimated from the available data):

  • Bloating and pain of the stomach
  • Headache
  • Dizziness
  • Depression
  • Breast tenderness
  • Hot flushes
  • Vaginal discharge
  • Joint pain
  • Urinary problems

Do not take Utrogestan if any of the following applies to you. If you are not sure about any of the points below, talk to your doctor or pharmacist before taking Utrogestan. You should also read the Package Leaflet before using this medicine.

Do not take Utrogestan:

  • If you are allergic (hypersensitive) to progesterone, soybean lecithin, peanut, soya, or to any of the other ingredients of this medicine;
  • If you have ever had breast cancer, or if you are suspected of having it;
  • If you have cancer which is sensitive to estrogens, such as cancer of the womb lining (endometrium), or if you are suspected of having it;
  • If you have any unexplained vaginal bleeding;
  • If you have or have ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism);
  • If you have a blood clotting disorder (such as protein C, protein S, or antithrombin deficiency);
  • If you have or recently have had a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina;
  • If you have or have ever had a liver disease and your liver function tests have not returned to normal;
  • If you have a rare blood problem called “porphyria” which is passed down in families (inherited);
  • If you have bleeding on the brain (cerebral haemorrhage);
  • If you are breast-feeding (see ‘Pregnancy and Breast-feeding’);
  • If any of the above conditions appear for the first time while taking Utrogestan, stop taking it at once and consult your doctor immediately;

Stop taking Utrogestan and see a doctor immediately if you experience any of the following when taking HRT:

    • Any of the conditions mentioned in the ‘DO NOT take Utrogestan 100mg’ section of the Package Leaflet
    • Yellowing of your skin or the whites of your eyes (jaundice). These may be signs of a liver disease;
    • A large rise in your blood pressure (symptoms may be headache, tiredness, dizziness);
    • Migraine-like headaches which happen for the first time;
    • Sudden or gradual, partial or complete loss of vision;
    • Forward displacement of the eye (proptosis) or double vision (diplopia);
    • Swelling of the optic nerve (papilloedema);
    • Eye diseases (retinal vascular lesions);
    • If you become pregnant;
    • If you notice signs of a blood clot, such as:
      • painful swelling and redness of the legs;
      • sudden chest pain;
      • difficulty in breathing;

For further information regarding HRT and cancer, cardiovascular risk, thrombosis and when to take special care with HRT, please click [here] for the Package Leaflet for Utrogestan 100 mg. You can also read more information [here] from NICE (NG23).

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in the package leaflet.

You can also report side effects directly via the Yellow Card Scheme at: or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.

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